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One older study found that high-dose intravenous glutathione was the most effective delivery method for people with fatty liver disease, and it significantly improved liver function tests several months after treatment

Studies have shown that changes in the gut microbiota down-regulate the expression of tight junction (TJs) proteins, leading to impaired intestinal barrier and bloodbrain barrier function, allowing biomacromolecules and microorganisms to penetrate the barrier, which in turn triggers neuroinflammatory responses (118)

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J Pharmacol Exp Ther 272:417422 Ajuebor MN, Zagorski J, Kunkel SL, Strieter RM, Hogaboam CM (2004) Contrasting roles for CXCR2 during experimental colitis